TXA:时间与方案TXA: timing and regimen
成人创伤活动/疑似严重出血;从受伤起算。Adults with active/suspected major traumatic bleeding; time from injury.
- ≤3 h;1 g 静滴 ≥10 min → 1 g 静脉维持 8 h。≤3 h; 1 g IV over ≥10 min → 1 g IV over 8 h.
- 尽早使用;国内 R33 维持表述为“8 h以上”,欧洲 R23 为8 h。Give early; Chinese R33 states at least eight hours for maintenance, European R23 eight hours.
- 超过3 h不常规使用;仅有黏弹性检测纤溶亢进证据时由上级结合本院方案决定,已知纤溶抑制者不用。Beyond three hours, not routine; only with viscoelastic hyperfibrinolysis evidence and senior/local-policy review; avoid known fibrinolytic shutdown.
中国休克共识2023Chinese shock2023 · 欧洲出血2023European bleeding2023 · NICE NG39NICE NG39
查适用差异、审核记录和原课Scope differences, review record and course
按本院药品说明书、配制及输注流程执行;不得快速静推。Follow local product, preparation and infusion policy; avoid rapid IV push.